I am originally from Sri Lanka and currently pursuing a PhD in Molecular Sciences at the University of Western Australia. My academic journey began with a Bachelor of Science in Biotechnology from Monash University Malaysia, followed by a Master of Biotechnology (Biochemistry and Molecular Biology) at UWA, where I graduated with Distinction. Alongside my studies, I have gained valuable research experience, including working as a Research Assistant at the University of Sri Jayewardenepura in Sri Lanka, where I focused on environmental microbiology and molecular biology. I have also completed internships in medical laboratory diagnostics and projects in nanotechnology and biomaterials. These diverse experiences have strengthened my interest in nanobiotechnology and biomedical applications, equipping me with both technical expertise and a multidisciplinary perspective that I now apply to my doctoral research.
My inspiration to pursue research stems from a deep fascination with how nanoscale technologies can address complex challenges in human health. During my master’s studies, I explored how DNA nanostructures interact with proteins and cells, which sparked my interest in their potential biomedical applications. This experience revealed the vast possibilities of nanobiotechnology in advancing targeted therapies and regenerative medicine. I was drawn to the ARC Training Centre for its interdisciplinary approach, collaborative environment, and focus on translating fundamental discoveries into impactful applications. The opportunity to work with leading researchers on cutting-edge projects aligned perfectly with my long-term goal of contributing to innovative, real-world healthcare solutions. Joining the centre was a natural step to further explore my passion while building the skills and collaborations necessary to make a meaningful impact.
My doctoral research project, “DNA Origami Nanostructures for iPSC Generation and Cell Reprogramming,” focuses on harnessing DNA nanotechnology to advance regenerative medicine. DNA origami is a powerful technique that enables the design of highly precise, programmable nanostructures. These can be engineered to interact with cells in unique ways, making them ideal candidates for delivering molecular cues that influence cell fate.
The goal of my research is to explore how DNA origami nanostructures can be used to enhance the efficiency and safety of induced pluripotent stem cell (iPSC) generation and cellular reprogramming. Conventional methods of reprogramming often face limitations, such as low efficiency and risks associated with viral vectors. By employing DNA nanostructures as delivery platforms, I aim to overcome these barriers, offering a more controlled, biocompatible, and versatile approach.
My work combines molecular biology, nanobiotechnology, and advanced cell-based techniques to investigate how these nanostructures interact with intracellular environments and guide reprogramming processes. The potential impact of this research is significant: it could pave the way for safer and more effective stem cell therapies, with applications ranging from disease modelling and drug testing to regenerative treatments for degenerative conditions. Ultimately, this project contributes to bridging fundamental nanoscience with transformative medical applications, specifically in Alzheimer’s treatments.
Through my research, I hope to contribute to advancing regenerative medicine by developing innovative, nanotechnology-based tools for stem cell biology. My ultimate goal is to improve the efficiency and safety of cell reprogramming techniques, enabling breakthroughs that will support personalised medicine, tissue engineering, and therapeutic applications. Beyond the laboratory, I aspire to contribute to the translation of these discoveries into real-world healthcare solutions that benefit patients and society. The ARC Training Centre provides the ideal platform to achieve these ambitions, offering state-of-the-art facilities, mentorship from world-class researchers, and an interdisciplinary community that fosters collaboration and innovation. I believe the centre’s resources and environment will not only strengthen my technical expertise but also prepare me to become a leader in nanobiotechnology and its biomedical applications.
